NEW! BRUKER timsUltra AIP

A Legacy of Innovation: Trapped Ion Mobility Mass Spectrometry

Trapped Ion Mobility Spectrometry (TIMS) has been transforming the trajectory of life-changing research from the very moment it launched. By adding a new fourth dimension of separation power and analytical depth, the timsTOF empowers researchers to tackle previously challenging questions and achieve breakthroughs that improve human health. Join us as we continue to defy the odds with TIMS. The possibilities are endless.

Dual-TIMS and CCS-enabled analysis

Trapped ion mobility spectrometry (TIMS) resolves sample complexity through an added dimension of gas phase separation on top of LC-MS. TIMS accumulates and concentrates ions (time-focusing effect) of a given mass-to-charge and mobility (based on cross sectional attributes). This allows for higher fidelity separation of noise from signal, which enables an increase in sensitivity with speed (> 100 Hz TIMS duty cycle). The 4th generation dual TIMS-XRTIMS achieves a near 100% duty cycle by accumulating ions in TIMS funnel 1, while ions in TIMS tunnel 2 are released sequentially (> 150 Hz). This process of parallel accumulation serial fragmentation (PASEF®) enables high speed collisional cross section (CCS) analysis.

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